By Felix R. Althaus, Hanna E. Kleczkowska (auth.), Rafael Alvarez-Gonzalez (eds.)
This distinct factor of Molecular and mobile Biochemistry includes twenty-two chosen study papers and experiences from a complete of 1 hundred and ten shows given on the twelfth foreign Symposium on ADP-ribosylation Reactions: From Bacterial Pathogenesis to melanoma, held in Cancun, Mexico, may well 10-14, 1997. The Symposium used to be hosted by way of the Sociedad Mexicana de Bioquimica and was once backed by way of the college of North Texas wellbeing and fitness technology heart, fortress worthy, TX, united states.
This quantity presents a cutting-edge resource of knowledge for easy scientists and clinicians who're drawn to the molecular, biochemical, and mobile features of protein-(ADP-ribose) move reactions in human healthiness and disease.
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Additional resources for ADP-Ribosylation Reactions: From Bacterial Pathogenesis to Cancer
Furthermore, it will be interesting to compare the shuttle vector data shown here with mutation rates of chromosomal genes, such as HPRT, in this cellular system. Results of previous inhibitor studies on the role of poly (ADP-ribosyl)ation in mutagenesis have been conflicting . This may have been due to differences in the experimental systems (including the mutational target genes) studied and! or to problems with the specificity of ADP-ribosylation inhibitors used under the various conditions.
Utakoji T, Hosoda K, Umezawa K, Sawamura M, Matsushima T, Miwa M, Sugimura T: Induction of sister chromatid exchanges by nicotinamide in Chinese hamster lung fibroblasts and human Iymphoblastoid cells. Biochem Biophys Res Commun 90: 1147-1152, 1979 20. Chatterjee S, Hirschler NV, Petzold SJ, Berger SJ, Berger NA: Mutant cells defective in poly(ADP-ribose) synthesis due to stable alterations in enzyme activity or substrate availability. Exp Cell Res 184: 1-15, 1989 21. Chatterjee S, Petzold SJ, Berger SJ, Berger NA: Strategy for selection of cell variants deficient in poly(ADP-ribose) polymerase.
Satoh MS, Lindahl T: Role of poly(ADP-ribose) formation in DNA repair. Nature 356: 356-358, 1992 6. Satoh MS, Poirier GG, Lindahl T: NAD(+)-dependent repair of damaged DNA by human cell extracts. J Bioi Chern 268: 5480-5487, 1993 7. Berger NA: Poly(ADP-ribose) in the cellular response to DNA damage. Radiat Res 10: 14-15, 1985 8. Heller B, Wang Z-Q Wagner EF, Radons J, Biirkle A, Fehsel K, Burkart V, Kolb H: Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells.