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2003) reported that circulating levels of IL-10 were elevated in obesity in women and reduced, along with those of IL-6 and CRP, in obese women without the metabolic syndrome after a significant [11 kg] loss of weight. , (2005) reported that after body weight reduction of 8 kg in android obese women there was no significant change in circulating levels of adiponectin or IL-10 while low adiponectin correlated with low IL-10 levels. , 2003). , 1994) and its absence leads to massive obesity in mice and men as well as delayed sexual maturation and immune defects (Dagogo-Jack, 2001; Gautron and Elmquist, 2011).

It is an acute phase protein secreted by the liver in response to stress and inflammation. , 2010). , 2010b). , 2004). Orsomucoid appears to be a unique inflammatory response protein whose circulating levels poorly respond to the degree of obesity or diabetes in humans. , 2010). , 2010). , 2011). Obesity effects on circulating OPG have been contradictory to say the least. , (2011) reported decreases in obesity. , (2010) concluded that there is no consensus on the relationship between BMI or other cardiovascular risk factors and the circulating levels of OPG much less the function of this protein in humans.

8-fold increase in fat cells over that in nonfat cells of omental adipose tissue. Bornstein (2009) pointed out that TSP-1 is synthesized and secreted by a wide variety of cells in culture including endothelial cells, fibroblasts and smooth muscle cells. Clearly TSP-1 is not an adipokine in the sense of being a protein preferentially expressed in fat cells but is rather found in all cells examined to date. The major function of TSP-1 is to regulate angiogenesis and knockout mice have an increased density of capillaries in cardiac and skeletal muscle.

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