By Scott H. Kaufmann MD, PhD (auth.), David A. Gewirtz, Shawn E. Holt, Steven Grant (eds.)
Apoptosis, Senescence and melanoma offers perception into proven practices and learn into apoptosis and senescence through completely reading novel and rising suggestions and study within the fields of mobile demise pathways, senescence progress arrest, medicinal drugs and resistance, DNA harm reaction, and different subject matters which nonetheless carry mysteries for researchers.
The quantity is split into six effortless to keep on with sections. the 1st is Apoptosis and substitute Modes of cellphone dying, by means of chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The 3rd half covers DNA harm reaction, Signaling Pathways and Tumorigenesis, whereas the fourth delves into Resistance and Sensitization. The booklet concludes with tested melanoma remedies and a piece which appears to be like towards the longer term with fresh and constructing melanoma Therapies.
In overall, this quantity presents uncomplicated scientists and clinicians with a deeper and extra entire knowing of the mobile responses of malignancies which could ensure the effectiveness of remedy, either within the preliminary phases of the disorder in addition to in illness recurrence.
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Extra resources for Apoptosis, Senescence, and Cancer
J Biol Chem 2003; 278:31469–72. 196. Jones JM, Datta P, Srinivasula SM, et al. Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature 2003; 425:721–7. 197. Martins LM, Morrison A, Klupsch K, et al. Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol Cell Biol 2004; 24(22):9848–62. 198. Hegde R, Srinivasula SM, Datta P, et al. The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein.
Milella M, Kornblau SM, Estrov Z, et al. Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest 2001; 108(6):851–9. 125. Catlett-Falcone R, Landowski TH, Oshiro MM, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999; 10:105–15. 126. Epling-Burnette PK, Liu JH, Catlett-Falcone R, et al. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.
The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2:489–501. 252. Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004; 304(5670):554. 253. Shayesteh L, Lu Y, Kuo WL, et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 1999; 21(1):99–102. 254. Kaufmann SH, Gores GJ. Apoptosis in cancer: cause and cure. Bioessays 2000; 22:1007–17. 255. Kennedy SG, Kandel ES, Cross TK, Hay N. Akt/protein kinase B inhibits cell death by preventing the release of cytochrome C from mitochondria.