By S. B. Field (auth.), Dr. med. Dipl. biochem. Rolf D. Issels, Prof. Dr. med. Wolfgang Wilmanns (eds.)
Physicians, biologists and physicists current their contemporary paintings within the box of hyperthermia in regards to either its program and its mixture with radiation and chemotherapy. present technical chances, medical administration and significant elements of its use for superficial and deep-seated tumors are mentioned. the most subject matters mentioned are: adjustments of metabolism and microcirculation lower than warmth stipulations, the organic interplay of warmth with X-rays and several other chemotherapeutic brokers, and the newest scientific facts from diverse associations at the mixed program within the remedy of cancer.
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Additional resources for Application of Hyperthermia in the Treatment of Cancer
Example text
25 50 100 150 200 time (min) Fig. 6. Decrease in pH in experimental tumours during a heat treatment at 43° C. Replotted after data from Song et al. (1980) and Vaupel (1982). Upper part. interstitial tumour pH; lower part, tern· perature manipulations; solid lines, C3H mammary adenocarcinoma (Vaupel 1982); dashed lines, Walker carcinoma (Song et al. co Co ° C i\ 00 1\1.? •. 007 180 exposure time ( min ) Fig. 7. Relative increase in size in tumours during hyperthermia. 5° C or sham·heating the tumour size was very accurately recorded with optical markers.
Upper part. interstitial tumour pH; lower part, tern· perature manipulations; solid lines, C3H mammary adenocarcinoma (Vaupel 1982); dashed lines, Walker carcinoma (Song et al. co Co ° C i\ 00 1\1.? •. 007 180 exposure time ( min ) Fig. 7. Relative increase in size in tumours during hyperthermia. 5° C or sham·heating the tumour size was very accurately recorded with optical markers. It appears that the tumour size increases slightly, but significantly, during the 3·h heating period 40 H. S. Reinhold substrate and vJ,bel tumour cells with Increased (anaerob1c) metaboUsm • lactate 8-hydroxybutyra te acetoacetate CO 2 velocity + sheer rllo + + pressure t , ...
I \......... : : .. 1 '" ........ 25 50 100 150 200 time (min) Fig. 6. Decrease in pH in experimental tumours during a heat treatment at 43° C. Replotted after data from Song et al. (1980) and Vaupel (1982). Upper part. interstitial tumour pH; lower part, tern· perature manipulations; solid lines, C3H mammary adenocarcinoma (Vaupel 1982); dashed lines, Walker carcinoma (Song et al. co Co ° C i\ 00 1\1.? •. 007 180 exposure time ( min ) Fig. 7. Relative increase in size in tumours during hyperthermia.