By B J A Furr
Read or Download Aromatase inhibitors PDF
Similar cancer books
Cancer Cell Culture: Methods and Protocols
With many contemporary advances, melanoma cellphone tradition examine is extra very important than ever sooner than. This well timed version of melanoma telephone tradition: tools and Protocols covers the fundamental innovations of melanoma mobilephone biology and tradition whereas increasing upon the hot shift in phone tradition tools from the new release of latest telephone traces to using fundamental cells.
Die tierische Zelle in Zellkultur
Die ersten erfolgreichen Versuche zur Züchtung tierischer Zellen außerhalb des Organismus reichen zurück in den Beginn unseres Jahrhunderts. 1907 gelang HARRI SON durch Explantation von Gewebsstücken aus Froschembryonen der Nachweis, daß in der Embryonalentwicklung die Neuriten als Fortsätze der Nervenzelle ohne Be teiligung anderer Zellen gebildet werden, und daß damit eine spezifische celluläre Funktion auch außerhalb des Gesamtorganismus zu beobachten ist [310,311].
Port-Site and Wound Recurrences in Cancer Surgery: Incidence - Pathogenesis - Prevention
Up to now nine years, experiences of 'port-site' deposits following laparoscopic surgical procedure for malignancy, specifically laparoscopic resection of colonic melanoma, have forged a shadow at the knowledge of the laparoscopic technique within the surgical guy agement in sufferers with melanoma. these stories of port-site deposits, a few ninety situations pronounced within the literature as much as 1999, have opened a 'can of worms' and highlighted the shortage of our wisdom on melanoma phone migration from reliable tu mors and the criteria that underlie their profitable implantation in surgical wounds either within the presence and lack of a favorable strain pneumoperito neum.
- Cancer and its Management, 6th Edition
- Cancer Chemo- and Immunopharmacology: 1. Chemopharmacology
- Standing On His Own Two Feet: A Diary Of Dying
- Stem Cells and Cancer Stem Cells, Volume 11: Therapeutic Applications in Disease and injury
Additional info for Aromatase inhibitors
Example text
This could contribute to the combination being rather less effective than letrozole alone. Figure 3. Effects of letrozole and tamoxifen and their combination on the growth of MCF-7CA breast tumour xenografts in female, ovariectomized, athymic nude mice. All mice received androstenedione (100 µg/day sc). Mice were divided into groups (n = 20 per group) and injected subcutaneously daily with vehicle, letrozole (10 µg/day) and/or tamoxifen (100 µg/day). Tumour volumes were measured weekly and are expressed as the percentage change relative to the initial tumour volume.
The selective approach would not interfere with other cytochrome P450 enzymes involved in the synthesis of essential hormones such as cortisol and aldosterone. Thus, selective aromatase inhibition would be a safer and more effective approach than antioestrogens. A number of compounds that are selective inhibitors of aromatase were first reported in 1973 [4]. Model systems for studying aromatase inhibitors in vitro During pregnancy, the placenta expresses high levels of aromatase in the syncytiotrophoblasts in the outer layer of the chorionic villi [5, 6] and is an excellent source of highly active enzyme [4, 7].
After extended treatment, tumours eventually grew during letrozole treatment. However, tumour-doubling time with letrozole was more than twice as long as with tamoxifen. Mice with tumours growing on letrozole treatment were then assigned to three groups so that each had similar mean tumour volumes at the start of second-line treatment. The groups were treated with either tamoxifen, a higher dose of letrozole (100 µg/day), or continued on letrozole (10 µg/day) treatment (Fig. 2) [80]. However, although the higher dose of letrozole slowed tumour growth, tumour volumes were not significantly different from those of groups treated with tamoxifen or continued on letrozole (10 µg/day).