By Stuart J Schnitt
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Extra resources for Biopsy Interpretation of the Breast
Sample text
Estrogen receptor-positive proliferating cells in the normal and precancerous breast. Am J Pathol. 1999;155(6):1811-1815. 34. Shaw JA, Udokang K, Mosquera JM, Chauhan H, Jones JL, Walker RA. Oestrogen receptors alpha and beta differ in normal human breast and breast carcinomas. J Pathol. 2002;198(4):450-457. 35. Shaaban AM, O’Neill PA, Davies MP, et al. Declining estrogen receptor-beta expression defines malignant progression of human breast neoplasia. Am J Surg Pathol. 2003;27(12):1502-1512. 36.
Am J Pathol. 2000;156(4):1109-1115. 49. Espina V, Geho D, Mehta AI, Petricoin EF 3rd, Liotta LA, Rosenblatt KP. Pathology of the future: molecular profiling for targeted therapy. Cancer Invest. 2005;23(1):36-46. 2 Reactive, Inflammatory, and Nonproliferative Lesions Some reactive, inflammatory, and nonproliferative lesions of the breast present problems clinically but are treated without resorting to a biopsy. In others, a biopsy is required to make the correct diagnosis and to distinguish the process from malignancy.
20, e-Fig. 14). 2. Although the pathogenesis of this condition is unknown, it may represent an autoimmune reaction. 20 Lymphocytic mastopathy/diabetic mastopathy. A: This breast biopsy shows stromal fibrosis, periductal and perivascular lymphocytic infiltrates, and epithelioid myofibroblasts in the stroma. B: High-power view of epithelioid myofibroblasts. 2 Key Histologic Features of Lymphocytic Mastopathy/ Diabetic Mastopathy • Keloidal fibrosis • Periductal, perilobular, and perivascular lymphocytic infiltrates • Epithelioid myofibroblasts in stroma Granulomatous Lesions As noted earlier, granulomatous inflammation may be seen in duct ectasia (Fig.