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1995; Yarden & Sliwkowski, 2001]. , 2007]. , 1994; Yarden & Sliwkowski, 2001b]. , 2007]. , 2007]. 1 Ras / Raf / mitogen-activated protein kinase (MAPK) pathway The Ras / Raf / mitogen-activated protein kinase (MAPK) pathway regulates cell proliferation and survival [Scaltriti & Baselga, 2006]. , 1994]. , 1994]. , 1994; Liebmann, 2001]. Activated MAPKs phosphorylate and regulate specific intranuclear transcription factors involved in cell migration and proliferation [Hill & Treisman, 1995; Scaltriti & Baselga, 2006 Gaestel, 2006].

ErbB-3 lacks intrinsic tyrosine kinase activity [Mass, 2004]. 24 Cancer of the Uterine Endometrium – Advances and Controversies The extracellular region of ErbB receptors has 4 subdomains (I-IV). Subdomains I and III (also called L1 and L2) are important for ligand binding. , 2002]. The EGF system has numerous ligands. According to their affinity for one or more ErbB receptors, they divided into three groups: 1. , 2003;]. 2. , 2003;]. 3. The third group includes ligands with binding specificity for ErbB-3 and ErbB-4: neuregulins (NRGs) or heregulins (HRGs).

Image cytometry DNA ploidy correlates with histological subtypes in endometrial carcinomas. Modern Pathology, Vol. W. (2007). 61-96, NY: Oxford University Press, New York Salvesen, H. , Iversen  O. Akslen, L. (1999). Prognostic significance of angiogenesis and Ki-67, p53 and p21 expression: apopulation-based endometrial carcinoma study. Journal of Clinical Oncology, Vol. A. et al. (2000). Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carinomas with poor prognosis.

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