By S.-I. Nishikawa, M. Osawa (auth.), O.D. Wiestler, B. Haendler, D. Mumberg (eds.)
This booklet describes the hot advancements within the rising box of melanoma stem cells. Their attainable impression for the identity of novel therapy paradigms for melanoma are mentioned. The booklet will commonly be of curiosity to scientists and clinicians thinking about melanoma examine, or to scholars wishing to go into into this area.
Read or Download Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy PDF
Best cancer books
Cancer Cell Culture: Methods and Protocols
With many fresh advances, melanoma cellphone tradition learn is extra very important than ever prior to. This well timed variation of melanoma mobilephone tradition: tools and Protocols covers the elemental options of melanoma mobile biology and tradition whereas increasing upon the new shift in mobilephone tradition tools from the iteration of recent mobile traces to using fundamental cells.
Die tierische Zelle in Zellkultur
Die ersten erfolgreichen Versuche zur Züchtung tierischer Zellen außerhalb des Organismus reichen zurück in den Beginn unseres Jahrhunderts. 1907 gelang HARRI SON durch Explantation von Gewebsstücken aus Froschembryonen der Nachweis, daß in der Embryonalentwicklung die Neuriten als Fortsätze der Nervenzelle ohne Be teiligung anderer Zellen gebildet werden, und daß damit eine spezifische celluläre Funktion auch außerhalb des Gesamtorganismus zu beobachten ist [310,311].
Port-Site and Wound Recurrences in Cancer Surgery: Incidence - Pathogenesis - Prevention
Prior to now nine years, experiences of 'port-site' deposits following laparoscopic surgical procedure for malignancy, in particular laparoscopic resection of colonic melanoma, have forged a shadow at the knowledge of the laparoscopic process within the surgical guy agement in sufferers with melanoma. these experiences of port-site deposits, a few ninety instances mentioned within the literature as much as 1999, have opened a 'can of worms' and highlighted the shortage of our wisdom on melanoma mobile migration from sturdy tu mors and the standards that underlie their profitable implantation in surgical wounds either within the presence and shortage of a favorable strain pneumoperito neum.
- Cancer Risk Coeffs for Environmental Exposure to Radionuclides (EPA 402-r-99-001)
- The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy
- Dietary Fat and Cancer: Genetic and Molecular Interactions
- Breast Reconstruction with Autologous Tissue Art and Artistry
- The Other Woman's Shoes
Extra info for Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy
Example text
2 Wnt Antagonists There are two groups of Wnt antagonists. The first includes the SFRP family, WIF-1 and Cerberus. They inhibit Wnt signaling by directly binding to Wnt molecules. The second group, which includes the Dickkopf (DKK) family, inhibits Wnt signaling by binding to the LRP5/ LRP6 component of the Wnt receptor complex (Kawano and Kypta 2003). These inhibitors have been extensively studied in developmental experiments, with demonstration of a role in oncogenesis, specifically in cervical (Ko et al.
3 Dishevelled (Dvl) . . . . . . . . . . . . 4 APC . . . . . . . . . . . . . . . . 5 β-Catenin . . . . . . . . . . . . . . 6 Non-canonical Pathway . . . . . . . . . . . 5 Potential Therapeutic Approaches Targeting the Wnt Pathway . 6 Summary . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 28 29 30 31 35 37 37 39 40 41 42 42 44 46 47 Abstract.
The link between Wnt-2 and tumorigenesis was first proposed after data indicated that Wnt-2 was amplified in human cancers (Yoshida et al. 1988). Similarly, Wnt-2 has been implicated in mouse mammary tumorigenesis through gene amplification (Roelink et al. 1992). Wnt-2 was later shown to be upregulated in gastric cancers (Nessling et al. 1998; Katoh 2001b), colorectal cancers (Vider et al. 1996; Holcombe et al. 2002; Katoh 2001c), and melanoma (Pham et al. 2003). Recently, we demonstrated overexpression of Wnt-2 in NSCLC (You et al.