By T. C. Thompson, S. A. Tahir, L. Li (auth.), Isabelle Mercier, Jean-François Jasmin, Michael P. Lisanti (eds.)
Caveolins are vital structural proteins of Caveolae, small invaginations of the membrane. they've been proven to play an incredible function within the pathogenesis of a number of cancers. during this quantity, we'll generally specialise in the significance of Caveolin-1 in breast, prostate, lung, epidermis, colon, pancreatic and mind cancers with additionally a point out of the radical function of Caveolin-3 in breast melanoma.
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Extra info for Caveolins in Cancer Pathogenesis, Prevention and Therapy
Sample text
A key objective of this chapter will be to highlight important aspects of this ongoing discussion and reconcile in a working model (see Fig. 3) these different and opposing functions of caveolin-1. In doing so, we will focus our attention mostly on studies dealing with the role of caveolin-1 in colorectal cancer. There, as will be eluded to in the next section, alterations in the so-called canonical Wnt signaling pathway are particularly important. 2 Caveolin-1 in Colon Cancer: The Flexible Connection to Wnt Signaling 19 Canonical Wnt Signaling in Colorectal Cancer: The Role of b-Catenin Colorectal cancer is one of the most common cancers and a leading cause of cancer death worldwide.
The lifetime risk of developing cancer in this population is estimated to be 5% [65]. Despite the fact that the incidence of this cancer has decreased in recent years as a result of the introduction of preventive measures, including the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and changes in life-style and nutrition, the disease still remains a major threat. Every year, some 550,000 patients worldwide continue to succumb to the disease [49]. In molecular and genetic terms, colorectal cancer is likely to be one of the bestunderstood solid malignancies.
Cell Cycle 4:1817–1825 87. Li L, Ren C, Yang G et al (2009) Caveolin-1 promotes autoregulatory, Akt-mediated induction of cancer-promoting growth factors in prostate cancer cells. Mol Cancer Res 7:1781–1791 88. Li L, Yang G, Ebara S et al (2001) Caveolin-1 mediates testosterone-stimulated survival/ clonal growth and promotes metastatic activities in prostate cancer cells. Cancer Res 61:4386–4392 89. Li S, Seitz R, Lisanti MP (1996) Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo.