By Allen G. Rodrigo, Gerald H. Learn Jr.
Computational and Evolutionary research of HIV Molecular Sequences is for all researchers drawn to HIV learn, even those that in basic terms have a nodding acquaintance with computational biology (or those who find themselves conversant in a few, yet now not all, features of the field). HIV examine is uncommon in that it brings jointly scientists from a variety of disciplines: clinicians, pathologists, immunologists, epidemiologists, virologists, computational biologists, structural biologists, evolutionary biologists, statisticians and mathematicians. This e-book seeks to bridge the distance among those teams, in either subject material and terminology. centred mostly on HIV genetic version, Computational and Evolutionary research of HIV Molecular Sequences covers such concerns as sampling and processing sequences, inhabitants genetics, phylogenetics and drug pursuits.
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Additional resources for Computational and Evolutionary Analysis of HIV Molecular Sequences
Sample text
1997), has been observed to differ among the long terminal repeats (LTRs) of different subtypes. Another difference between subtypes that is of potentially biological significance is reflected in subtype specific patterns of genetic variation. , 1994b), and apparently in a subset of CRF01_AE viruses, compared with other subtypes. , 1996). The V3 loop is a functionally important domain of the viral envelope. , 1997). , 1994b). , 1998). Recently, the analysis presented by Korber in 1994 was repeated using the vastly increased number of V3 sequences that are now available in the Los Alamos database.
1994). , 1994), suggesting that this branch of the epidemic results from import rather than local transmissions. , 1998b). There appear to be three main lineages of subtype A at present. The first is composed of isolates from Central and East Africa. The sec- ond one is found mainly in West Africa (Ivory Coast and Liberia) and in Djibouti, where it was presumably introduced by soldiers of the French Foreign Legion who had contracted the infection in West Africa. The subtype A portions of CRF01_AE constitute the third lineage which always clusters tightly together separate from the Computational and Evolutionary Analyses of HIV Molecular Sequences 33 other subtype A sequences.
For historical consistency, the B and D designations will remain. However, if new lineages 7) 4. , 1999). , 1994a) could be more generally adopted. In particular, sequences should be named with a two-letter country code designation that refers to the country the person was living when sampled, and the year of sampling. The laboratory identifier and clone number should also be indicated in the name. USES OF THE SUBTYPE CLASSIFICATION The classification scheme of HIV-1 into subtypes has proven useful in the phylogenetic analysis of new sequences and in clarifying epidemiological relationships and possible ancestry of HIV.