By J Timothy Wright
This e-book presents the practitioner with a framework for developing a prognosis and constructing an appropriate remedy plan in sufferers proposing with quite a number developmental defects of enamel. The stipulations lined contain failure of teeth eruption, hypodontia, untimely enamel exfoliation, defects of teeth improvement, and defects of dentin improvement, with complete attention of either syndromic and non-syndromic defects. In every one case the phenotype and genotype are first defined, by way of diagnostic info, together with the provision of genetic trying out, and remedies. Summarizing tables are used to focus on the most important diagnostic gains, and worthy illustrated case displays are integrated. Cleft palate can be addressed, with info on etiology, phenotypes, therapy timing and methods, and dental administration. The final bankruptcy presents stimulating reflections on strength destiny instructions within the analysis and therapy of those disorders.
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Extra info for Craniofacial and Dental Developmental Defects: Diagnosis and Management
Example text
Coffin-Lowry Syndrome Children with Coffin-Lowry syndrome (OMIM #303600), an X-linked inherited condition caused by mutations in a growth factor-related gene [1, 8], present with intellectual disabilities and skeletal anomalies [1, 8–10]. These children present with classic facial features related to the persistent anterior fontanel (Fig. 1). Thick hands, extensible joints, and hypotonia along Fig. 1 Typical facial appearance of Coffin-Lowry syndrome with sensorineural hearing loss are all common features [1, 8–10].
Down Syndrome Down syndrome (OMIM #190685) (trisomy 21) is a genetic condition associated with many congenital anomalies including a characteristic facial appearance [40]. These features include upwardly sloping eyes with a bridge of the nose that is depressed more than normal [37]. Many of these children also have malformations of the external part of the ear. More consequential abnormalities are also present such as chronic respiratory infections, impaired immunity, and cardiac problems [40].
268–88. 12. Cahill DR, Marks Jr SC. Tooth eruption: evidence for the central role of the dental follicle. J Oral Pathol. 1980;9(4):189–200. 13. Marks Jr SC, Cahill DR. Regional control by the dental follicle of alterations in alveolar bone metabolism during tooth eruption. J Oral Pathol. 1987;16(4):164–9. 14. Wise GE, Frazier-Bowers S, D'Souza RN. Cellular, molecular, and genetic determinants of tooth eruption. Crit Rev Oral Biol Med. 2002;13(4):323–34. Review. 15. Beertsen W, Hoeben KA. Movement of fibroblasts in the periodontal ligament of the mouse incisor is related to eruption.