By Anupama Gururaj, Rakesh Kumar (auth.), Leonidas C. Platanias MD, PhD (eds.)
This quantity presents a accomplished evaluate of the present wisdom on cytokines and melanoma. Cytokines play a number of roles in melanoma, either as elements of pathogenetic mechanisms, in addition to brokers utilized in the remedy of sure malignancies. thus far, there has now not been a e-book released that covers either uncomplicated technology and translational/clinical study within the box of cytokines in malignancies.
The quantity is split in sections. part one makes a speciality of present advancements within the simple technology box with specific emphasis on novel mechanisms of cytokine activities in malignant cells. the second one part offers with translational and medical learn within the box, and plenty of of the bankruptcy authors have been one of the first to introduce numerous cytokines within the therapy of convinced tumors.
Cytokines and Cancer is written by way of top figures within the box of cytokine biology and cytokine therapeutics and is particularly all for this topic.
Collectively, the data supplied during this ebook could be necessary to humans within the clinical box at a number of degrees, together with scientific scholars, interns, citizens, medical and uncomplicated technological know-how researchers, in addition to oncologists in practice.
Read or Download Cytokines and Cancer PDF
Similar cancer books
Cancer Cell Culture: Methods and Protocols
With many fresh advances, melanoma phone tradition learn is extra vital than ever ahead of. This well timed version of melanoma mobile tradition: tools and Protocols covers the fundamental suggestions of melanoma cellphone biology and tradition whereas increasing upon the new shift in phone tradition equipment from the new release of recent cellphone traces to using fundamental cells.
Die tierische Zelle in Zellkultur
Die ersten erfolgreichen Versuche zur Züchtung tierischer Zellen außerhalb des Organismus reichen zurück in den Beginn unseres Jahrhunderts. 1907 gelang HARRI SON durch Explantation von Gewebsstücken aus Froschembryonen der Nachweis, daß in der Embryonalentwicklung die Neuriten als Fortsätze der Nervenzelle ohne Be teiligung anderer Zellen gebildet werden, und daß damit eine spezifische celluläre Funktion auch außerhalb des Gesamtorganismus zu beobachten ist [310,311].
Port-Site and Wound Recurrences in Cancer Surgery: Incidence - Pathogenesis - Prevention
Prior to now nine years, reviews of 'port-site' deposits following laparoscopic surgical procedure for malignancy, particularly laparoscopic resection of colonic melanoma, have solid a shadow at the knowledge of the laparoscopic strategy within the surgical guy agement in sufferers with melanoma. these stories of port-site deposits, a few ninety circumstances stated within the literature as much as 1999, have opened a 'can of worms' and highlighted the shortage of our wisdom on melanoma cellphone migration from sturdy tu mors and the criteria that underlie their winning implantation in surgical wounds either within the presence and shortage of a favorable strain pneumoperito neum.
- Therapeutic Strategies in Primary and Metastatic Liver Cancer
- Signaling Pathways in Cancer Pathogenesis and Therapy
- Novel Approaches to Cancer Chemotherapy
- Cures for All Cancers
- Fighting Back with Fat
Additional info for Cytokines and Cancer
Example text
290(2): p. 289-302. , L. Ruuls-Van Stalle, and E. Roos, The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Res, 2003. 63(13): p. 3833-9. , Expression of stromal cell-derivedfactor I and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression. Clin Cancer Res, 2000. 6(9): p. 3530-5. , Stromal cell-derived factor lalpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt.
J Immunother, 2003. 26(2): p. 11729. 102. , Fractalkine transgene induces T-cell-dependent antitumor immunity through chemoattraction and activation of dendritic cells. Int J Cancer, 2003. 103(2): p. 212-20. 103. , Fractalkine mediates natural killer-dependent antitumor responses in vivo. Cancer Res, 2003. 63(21): p. 7468-74. 104. 'par. Cancer Res\par, 2001. 61\par(23\par): p. 8498-503\par. 105. , Adenovims-mediated delivery of antiangiogenic genes as an antitumor approach. 8(1): p. 45-54. 106.
The observation that all ELR+ CXC chemokines bind CXCR2, while ELR- angiostatic chemokines CXCL9 and CXCLlO bind CXCR3, suggests that receptor hnction and expression rather than the presence or absence of ELR sequence may account for the role of specific chemokines in angiogenesis [64]. CXCL8 was the first chemokine to display potent angiogenic activity when implanted into rat cornea and to induce proliferation and chemotaxis of human umbilical vein endothelial (HUVEC) cells [53]. A CXCL8 antisense oligonucleotide specifically blocked the production of monocyteinduced angiogenic activity, suggesting a role for CXCL8 in angiogenesisdependent disorders.