By John F.R. Robertson, Robert I. Nicholson, Daniel F. Hayes
This article stories the most recent rules in tumor biology, explains the pharmacologic foundation of the brokers used, and discusses how they're utilized in medical perform. half One offers an summary of the medical significance of endocrine remedy, and describes the functions of the valuable periods of substances, together with antiestrogens, aromatase inhibitors, progestins, and progesterone receptor antagonists. This part additionally discusses ovarian ablation. half offers with the organic points of endocrine remedies, and relates present figuring out of tumor biology and the pharmacologic foundation of hormonal brokers to their medical functions. one of the themes coated are resistance and sensitivity to treatment. half 3 outlines destiny recommendations, specifically using blend endocrine remedy, adjuvant progress issue remedy and using anti-invasive brokers. this article is key for oncologists and pharmacologists alike.
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Additional info for Endocrine Therapy of Breast Cancer
The Ontario Cancer Treatment and Research Foundation Clinical Trial on the comparative effect of ovarian irradiation in carcinoma of the breast in the postmenopausal patient. In: Treatment of Early Breast Cancer 1: Worldwide Evidence 1985–1990. A Systemic Overview of All Available Randomized Trials of Adjuvant Endocrine and Cytoxic Therapy (Early Breast Cancer Trialists’ Collaborative Group). Oxford: Oxford University Press, 1990. Delozier T, Juret P, Couette JE, Mace-Lesech J. Ovarian irradiation in postmenopausal women with breast cancer and positive axillary nodes.
As a result, studies that have compared firstgeneration regimens with endocrine manoeuvres cannot indicate how the latter would compare with second-generation regimens. This sort of indirect conclusion is somewhat unsatisfactory, and it is to be hoped that more direct comparisons of ovarian ablation and chemotherapy will be carried out in the future in order to further delineate their relative roles in premenopausal women. Comparability of tamoxifen with ovarian ablation and with chemotherapy There have been no randomized trials comparing tamoxifen with ovarian ablation in the adjuvant setting in premenopausal women.
Cyclophosphamide, methotrexate, and fluorouracil versus tamoxifen plus ovarian suppression as adjuvant treatment of estrogen receptor-positive pre-perimenopausal breast cancer patients: results of the Italian Breast Cancer Adjuvant Study Group 02 randomized trial. it J Clin Oncol 2000; 18: 2718–27. Love RR, Mohsin SK, Havighurst T, Allred CC. Overexpression of Her-2 neu as a prognostic factor and as a predictive factor for response to adjuvant combined endocrine therapy in premenopausal Vietnamese women with operable breast cancer.