By Polina Prokopovich
Half 1 basics and issues of inhaler units: Anatomy and pathophysiology of respiration method; historical past of inhaler units; Tribology of inhaler units and parts; Novel coatings and biotechnology traits in inhaler units; Microbial keep an eye on and security in inhalation units. half 2 Drug formulations for inhaler units: Chitosan and inhalers: A bioadhesive polymer for pulmonary drug supply; Polyelectrolyte assemblies for drug garage and supply: Multilayers, nanocapsules, and multicapsules; Functionalized core-shell nanoparticles for clinical purposes.
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Additional resources for Inhaler Devices Fundamentals, Design and Drug Delivery.
Sample text
B. and Dhand, R. 2011. Aerosol drug delivery: developments in device design and clinical use. The Lancet, 377, 1032–1045. Fink, J. B. 2000. Metered-dose inhalers, dry powder inhalers, and transitions. Respiratory Care, 45, 623–635. Flament, M. , Burnouf, T. and Gayot, A. T. 1997. Jet nebulisation: influence of dynamic conditions and nebuliser on nebulisation quality. Application to the α 1 protease inhibitor. International Journal of Pharmaceutics, 148, 93–101. © Woodhead Publishing Limited, 2013 28 Inhaler devices Fradely, G.
Et al. 2011. Device type and realworld effectiveness of asthma combination therapy: an observational study. Respiratory Medicine, 105, 1457–1466. Rubin, K. B. and Fink, J. B. 2005. Optimising aerosol delivery by pressurised metereddose inhalers. Respiratory Care, 50, 1191–1200. Smaldone, G. C. 2005. Assessing new technologies: patient–device interactions and deposition. Respiratory Care, 50, 1151–1160. Smith, J. and Tiner, R. Aerosol drug delivery: developments in device design and clinical use.
Using the DPI technique, respiratory delivery of other potent drugs such as insulin, antibiotics, drugs for neurological disorders like Parkinson’s disease, antituberculosis, antihypertensive nifedipine, anticoagulant heparin, drugs for sexual dysfunction, opioids and fentanyl for cancer pain (Islam and Gladki, 2008) have been tested. Furthermore, the delivery of atropine sulphate nanoparticles as an antidote for organophosphorus poisoning with better bioavailability has been investigated. Therefore, research reveals that there is a growing interest in pulmonary delivery of various drugs for the management of systemic disorders.