By Yasuhiko Sakata MD, PhD (auth.), Ichiro Wakabayashi, Klaus Groschner (eds.)
This e-book offers an creation to the foundations of either cardiovascular epidemiology and molecular pathophysiology; as a different point, it additionally outlines and discusses the molecular techniques underlying epidemiological observations. This 3rd quantity is concentrated at the most typical “cardiovascular occasions” to supply an summary on pathogenesis and scientific features. The publication promotes using interdisciplinary ways within the box of preventive drugs in keeping with contemporary advances in molecular and mobile pathophysiology. The booklet bargains a important source for researchers in easy biomedical fields and medical scientists alike, in addition to guidance for novel avenues of analysis in either easy pathophysiology and cardiovascular treatment and prevention.
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Additional info for Interdisciplinary Concepts in Cardiovascular Health: Volume III: Cardiovascular Events
Example text
In addition to stroke events, CSVD has been shown to be related to cognitive function and future risk of dementia and cognitive decline (Moorhouse and Rockwood 2008). 5 K. Kitagawa Inflammation in the Cerebral Vessels: A New Mechanism Underlying Cerebral Atherosclerosis and Arteriosclerosis? In addition to traditional risk factors, low-grade inflammation has been attracting much attention in the study of the vascular biology underlying atherosclerosis. Plaque rupture and erosion have been observed in atherothrombotic brain infarction (Ogata et al.
2006; Ovbiagele et al. 2011). Diabetes mellitus has been consistently shown as a risk factor for cerebral infarction, but the association between diabetes mellitus and cerebral hemorrhage is a subject of debate (Emerging Risk Factors Collaboration et al. 2010a). Although it remains unclear whether the strict control of blood sugar levels reduces the risk of stroke (ACCORD Study Group et al. 2008), blood pressure control and statin treatment in dyslipidemic diabetes patients reduce the risk of stroke (ACCORD Study Group ACCORD Study Group et al.
Jpn Circ J 64:1–12 Shimokawa H, Rashid M (2007) Development of Rho-kinase inhibitors for cardiovascular medicine. Trends Pharmacol Sci 28:296–302 Shimokawa H, Takeshita A (2005) Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler Thromb Vasc Biol 25:1767–1775 Shimokawa H, Yasuda S (2008) Myocardial ischemia: current concepts and future perspectives. J Cardiol 52:67–78 Shimokawa H, Ito A, Fukumoto Y, Kadokami T, Nakaike R, Sakata M, Takayanagi T, Egashira K, Takeshita A (1996) Chronic treatment with interleukin-1-induces coronary intimal lesions and vasospastic responses in pigs in vivo.