By Sven Otto
Osteonecrosis of the jaws is a widely known side-effect of antiresorptive remedy that predominantly happens in sufferers struggling with malignant illnesses and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. much less often it could actually even be saw in sufferers with osteoporosis who're being taken care of with those antiresorptive medications
This textbook presents specified, up to date details on all features of medication-related osteonecrosis of the jaws, together with medical positive factors, pathogenesis, treatments, and preventive measures. It additionally explains secure prevention and therapy ideas for sufferers receiving antiresorptive medicines who require extractions, implant insertions, and different dento-alveolar surgical procedures. This publication should be of significant curiosity for clinical and dental scholars, dentists, and oral and maxillofacial surgeons in addition to osteologists and oncologists.
Read Online or Download Medication-Related Osteonecrosis of the Jaws: Bisphosphonates, Denosumab, and New Agents PDF
Best dentistry books
Osseointegration and Dental Implants
Osseointegration and Dental Implants deals a complete advisor to the cutting-edge of implant dentistry. dependent round the lawsuits of the Toronto Osseointegration convention Revisited, it gathers jointly info on all elements of implant dentistry and osseointegration, from uncomplicated medical history, corresponding to the biology of osseointegration and the biomechanics of implant floor layout, to scientific relevance, corresponding to remedy making plans, loading protocols, and sufferer rehabilitation.
Nonproliferation issues for weapons of mass destruction
Nonproliferation matters for guns of Mass Destruction offers an knowing of WMD proliferation dangers via bridging complicated technical and political matters. The textual content starts off via defining the area stipulations that foster proliferation, by way of an research of features of varied sessions of WMDs, together with nuclear, organic, and chemical guns.
Textbook of Dental Anatomy, Physiology and Occlusion
This textbook is a accomplished advisor to dental anatomy, body structure and occlusion (alignment), for postgraduate dental scholars. starting with an creation to anatomy and the teeth improvement, the next chapters supply extensive dialogue on deciduous and everlasting dentition, morphology of tooth, and occlusion.
Carranza’s Clinical Periodontology
The main definitive and familiar periodontology textual content for either the school room and medical perform, Carranza's medical Periodontology, twelfth variation contains the most up-tp-date periodontal details – from simple technology and primary systems to the newest complicated recommendations in reconstructive, esthetic, and implant treatment.
- Color Atlas of Endodontics
- Integrated Clinical Orthodontics
- Oxford American Handbook of Clinical Dentistry (Oxford American Handbooks in Medicine)
- Applied Dental Materials (9th Edition)
- Periodontal Disease: Symptoms, Treatment and Prevention (Dental Science, Materials and Technology)
- Prevention in clinical oral health care
Extra resources for Medication-Related Osteonecrosis of the Jaws: Bisphosphonates, Denosumab, and New Agents
Sample text
This might be attributed to the limited number of cohort studies or case–control studies that can ensure an adequate level of scientific evidence. Therefore, the reported risk factor for BRONJ related to oral BP was based on the frequency of co-morbidity in a case series. Patients without systemic or local risk factors rarely develop BRONJ after oral bisphosphonate intake alone. A retrospective cohort study of 30 oral BRONJ patients [61] showed that diabetes (33 %) and systemic inflammatory disorders (20 %) involving long-term corticosteroid use (23 %) were the most common co-morbidities.
Risk Factors for DenosumabRelated ONJ Denosumab is a human monoclonal antibody against the receptor activator of nuclear factor kappa-B ligand (RANKL). Denosumab inhibits the RANKL, an important mediator of osteoclastic differentiation [106]. As an antiresorptive agent, denosumab reduces osteoclastogenesis and is widely used for the treatment of metastatic bone disease and osteoporosis [107–110]. It had been proposed that inhibition of RANK– RANKL interaction by denosumab may also influence monocyte migration and decrease cell survival [111], which may be related to ONJ development.
Therefore, the reported risk factor for BRONJ related to oral BP was based on the frequency of co-morbidity in a case series. Patients without systemic or local risk factors rarely develop BRONJ after oral bisphosphonate intake alone. A retrospective cohort study of 30 oral BRONJ patients [61] showed that diabetes (33 %) and systemic inflammatory disorders (20 %) involving long-term corticosteroid use (23 %) were the most common co-morbidities. 2 %) were the major co-morbidities [58]. In some reports, hypertension or cardiac disease was the most frequent systemic disease in oral BRONJ patients [70, 71].