By Kenneth R. Chien MD PhD, Kenneth R. Chien
The second version of this heralded spouse to Braunwald's center ailment explores the molecular mechanisms of cardiology and the clinical advances which are altering the perform of cardiology this present day. foreign specialists speak about the function of genetics in heart problems · the molecular foundation of ischemic affliction, thrombosis and high blood pressure · genetic mapping ways to inherited issues · biologically designated brokers for high blood pressure and middle failure · and lots more and plenty extra. ample figures and tables illustrate key concepts.
- Addresses commonest cardiovascular difficulties from a molecular standpoint.
- Explores constructing remedies for cardiovascular difficulties in keeping with genetics.
- Provides references to Braunwald's middle illness, sixth Edition
- Examines state-of-the-art innovative advances in molecular cardiology and the way forward for gene therapy,
- Examines the results of mobile ldl cholesterol metabolism in healthiness and disease.
- Delivers up to date info on figuring out the foundation of inherited disease.
With fifty five extra contributing specialists.
Read or Download Molecular Basis of Cardiovascular Disease. A Companion to Braunwald's Heart Disease PDF
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Extra info for Molecular Basis of Cardiovascular Disease. A Companion to Braunwald's Heart Disease
Example text
HUMAN GENOME PROJECT AND CARDIOVASCULAR DISEASE GENES The impact of the HGP and related ongoing HGP-related projects on the discovery of disease genes has been significant. Before the beginning of the HGP, disease genes were discovered by a laborious process, moving from identification of the relevant metabolic defect and distinguishing the protein involved, to gene cloning and mapping, and finally to searching for mutations in the sequence. This approach led to the discovery of genes for several diseases such as sickle cell anemia and Fabry’s disease.
Asterisks (*) denote genes for which adult heart gene frequencies differed significantly from fetal heart frequencies, and for which p-values were determined using adult heart EST data alone as the reference value. Gene denotes the gene name; Accession denotes the Genbank accession number for each gene; Function denotes the functional category for each gene; Fetal denotes the expression frequency for the human fetal heart; Adult denotes the expression frequency for the human adult heart; Dis denotes the expression frequency for the human hypertrophic heart; p denotes the probability for differential expression in the hypertrophic against the normal heart.
Despite new and exciting information, even monogenic disorders can be complex in their genetic heterogeneity. In the following section we very briefly discuss FHC, DCM, and long QT syndrome as examples of three monogenic cardiac diseases whose definition has been speeded up by technologies developed through the HGP. 103,104 FHC is a highly heterogenous disease. Its clinical manifestations range from few symptoms and normal life expectancy to severe symptoms and sudden death. Of prognostic interest, mutations in genes associated with FHC can potentially predict the clinical course of disease.