By Zhongjie Sun
Read or Download Molecular Cardiology: Methods and Protocols (Methods in Molecular Medicine) PDF
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Extra info for Molecular Cardiology: Methods and Protocols (Methods in Molecular Medicine)
Example text
Moreover, this technique could be combined with cardiac-specific or regulatable promoters to reduce the toxicity of uncontrolled transgene expression further (16,17). 2. 1. Technique 1: Selective Coronary Gene Delivery 1. 2. 3. 4. 5. 100 mg/mL Ketamine (Abbott Laboratories, North Chicago, IL). Lidocaine HCl (Abbot Laboratories). Contrast liquid (Renografin®-60, Bracco Diagnostics, Princeton NJ). Heparin (Elkins-Sinn, Cherry Hill, NJ). Phosphate buffered saline (PBS; Dulbecco’s phosphate-buffered saline, GibcoBRL, Life Technologies, Grand Island, NY).
Therefore, we want to design a gene therapy strategy for the ischemic heart, which expresses cardioprotective genes on hypoxic ischemic attacks but keeps silent during nonischemic intervals, since constitutive overexpression of transgenes may lead to deleterious side effects. In the current study, we utilized hypoxia response element to regulate transgene expression in response to hypoxia. How to increase the expression level of transgenes to reach the optimal therapeutic level is another problem facing gene therapy.
Contrast liquid (Renografin®-60, Bracco Diagnostics, Princeton NJ). Heparin (Elkins-Sinn, Cherry Hill, NJ). Phosphate buffered saline (PBS; Dulbecco’s phosphate-buffered saline, GibcoBRL, Life Technologies, Grand Island, NY). 04/Jones/49-58/F2 51 11/5/04, 9:00 AM 52 Jones and Koch 6. Surgical instruments: surgical blade no. 15 (Becton Dickinson), scissors, pickups, right-angle forceps, atraumatic bulldog clamp. 7. Sutures: 2/0 silk, 3/0 vicryl (Ethicon, Somerville, NJ). 8. 24-Gage cannula (Quik-Cath®, Baxter Healthcare Corporation).