By R. J. Ellis (auth.), R. J. Ellis, R. A. Laskey, G. H. Lorimer (eds.)
Currently one of many most well liked issues in biochemistry, the concept that of molecular chaperones has challenged the paradigm of protein self-assembly. Key figures in lots of disciplines evaluation all points of molecular chaperones during this quantity, which arises from a Royal Society dialogue assembly. assessment chapters talk about the importance of chaperones in biochemistry, molecular genetics and mobile biology. every one bankruptcy is definitely referenced supplying entry to the literature.
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Presently one of many most well liked themes in biochemistry, the concept that of molecular chaperones has challenged the paradigm of protein self-assembly. Key figures in lots of disciplines evaluation all facets of molecular chaperones during this quantity, which arises from a Royal Society dialogue assembly. review chapters talk about the importance of chaperones in biochemistry, molecular genetics and phone biology.
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ADGA---M .. M ..... A.. HCV .... LD ... QYI. L. VF ...... I. KER .. L. Q. A Clp A ...... AASGGQ--V .... LI.. L.. KlR ... 5.. YQ. FSN. F... LA ...... DIT ... lEE .. IN .. K.... G.. D.. YTAK. VRA Hsp104 AAQLAKRYLPYRRLPDSALDLVDlSCAGVAVARDSKPEELDSKEQSIAIDSSRDKSSRERVECRLHTKRKLKLARQKEASLQEELEPLRQRYNEEKHGHE Clp B .. SH .. Q ... I .. EAASSIRMQI ........ EEEWKA .. VE .. H ... MPV .. GK .. ELE .. VL .. W..... SRMM ... R... LR .. ESVV .. IAR .. I. NE. VD ..... R .. A... IG ...... PT. V..... DSDEA. V. M ..
Our results do not exclude the possibility that hsp 104 functions to stimulate the proteolysis of protein aggregates that accumulate at high temperatures. Indeed, in E. coli the general proteolytic defects of ClpA mutants are subtle, becoming apparent only when the influence of an additional protease is eliminated by mutation (Katayama et al. 1988). However, given the 100- to 1000-fold increase in thermo tolerance seen in the presence of the hsp 104 protein, it seems unlikely that such a subtle role in protein degradation is its primary function.
L. 1990 HSP 104 required for induced thermotolerance. Science, Wash. 248, 1112-1115. , Borkovich, K. L. 1990 Hsp 104 is required for tolerance to many forms of stress. Science, Wash. 248, 1112-1115. A. L. 1993 Genetic evidence for a functional relationship between hsp 104 and hsp 70. ) Seufert, W. & Jentsch, S. 1990 Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins. EMBO J. 9, 543550. , McGarry, T. & Lindquist, S. 1991 Changes in Hsp 70 Alter Thermotolerance and Heat-Shock Regulation in Drosophila.