By Irene Bosch, James M. Croop MD, PhD (auth.), Martin Clynes (eds.)
Resistance to chemotherapy, and particularly multi-drug resistance, represents an important barrier to the profitable therapy of melanoma. This multi-author quantity brings jointly a variety of updated stories on diverse points of our wisdom of drug-resistance mechanisms, written by means of specialists within the assorted components. specific awareness is paid to lately found mechanisms on the subject of oncogene expression and specifically to proteins curious about law and execution of apoptosis. different very important subject matters lined contain DNA fix, topoisomerases, mobile cycle regulate, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. fresh advancements in figuring out the position of efflux pumps (P-170, MRP) in multi-drug resistance also are reviewed. This ebook might be worthy to clinicians and scientists operating within the components of chemotherapy, drug resistance, DNA fix and apoptosis research.
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Baichwal V. Liu D and Ames GF (1993) The ATP-binding component of a prokaryotic traffic ATPase is exposed to the periplasmic (external) surface. Proc Natl Acad Sci 90: 620--624. Bairoch A (1992) PROSITE: a dictionary of sites and patterns in proteins. Nucleic Acids Res 20. Suppl: 2013-2018. Balzi E and Goffeau A (1995) Yeast multidrug resistance: the PDR network. J Bioenergetics Biomembranes 27: 71-76. Beck WT (1990) Multidrug resistance and its circumvention. Eur J Cancer 26: 513-515. Beja 0 and Bibi E (1995) Multidrug resistance protein (Mdr)alkaline phosphatase hybrids in Escherichia coli suggest a major revision in the topology of the C-terminal half of Mdr.
Proc Natl Acad Sci USA 92: 973-977. Zhang JT, Lee CH, Duthie M and Ling V (1995) Topological determinants of interual transmembrane segments in p-glycoprotein sequences. J Bioi Chern 270. Zhang JT and Ling V (1995) Involvement of cytoplasmic factors regulating the membrane orientation of P-glycoprotein sequences. Biochem 34: 9159-9165. Address for correspondence: James M. A. Cytotechnology 27: 31-60,1998. © 1998 Kluwer Academic Publishers. 31 Molecular analysis of the muItidrug transporter, P-glycoprotein Ursula A.
Cancer Res 30: 1174-1184. Bosch T and Croop JM (1996) P-glycoprotein multidrug resistance and cancer. Biochim Biophys Acta 1288: F37-F54. Bosch I, Ounussi-Joannopoulos K, Wu RL, Furlong Sand Croop JM (1997) Phosphatidylcholine and Phosphatidyletbanolamine are substrates of human MDRI P-glycoprotein. Biochem (in press). Bosch I, Jackson GR, Croop JM and Cantiello HF (1996) Expression of Drosophila melaogaster P-glycoproteins is associated with ATP-channel activity. Am J Physiol40: CI527-CI538. Bosch I, Wang Z, Tao L and Shoemaker C (1994) TwoSchistosoma Manonsi cDNAs encoding ATP binding cassette (ABC) family proteins.