By Bruce S. Schoenberg
When requested why he robbed banks, an astute and good fortune ful felony is related to have answered "Because that is the place the money is kept." Why research sufferers with a number of basic cancers? the reply follows an identical useful procedure. as the in depth research of such sufferers is especially prone to yield info helpful to either the scientific and study on cologist. experiences of this challenge offer an instantaneous go back for the clinician answerable for the care of melanoma sufferers. With better varieties of treatment, those people are having fun with longer classes of survival. One vital think about protecting elevated survival is the early detection and remedy of recent basic tumors that can increase. Analyses of a number of basic malignancies function a advisor to the possible anatomic place of a next basic and support outline features of the person at excessive danger for a number of fundamental melanoma. yet simply as therapy may possibly enhance the lifetime of the melanoma sufferer, it will probably additionally bring up the chance of a next malignancy. experiences of a number of primaries offer an effective capability for quantifying possibly damaging results of present healing modalities.
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Additional resources for Multiple Primary Malignant Neoplasms: The Connecticut Experience, 1935–1964
Example text
Cases reported by death certificate only are included in the calculation of incidence rates. Use of the age at death for the age at diagnosis tends to increase the incidence rates for older age groups. It may be that the group who already developed one cancer is more closely followed medically than the population who has not developed a malignancy, so that subsequent cancers are likely to be discovered more often and earlier in patients who have had a cancer. The group with one cancer already diagnosed may be more health conscious, or may come from areas of the state with better medical diagnostic facilities than the population in general, so that any second cancer may be diagnosed earlier.
The question arises as to whether these patients have an intrinsic abnormality of their reticuloendothelial system which leads to malignant transformation, or whether the high occurrence of malignancies is the result of the immunosuppression. Observations such as these have prompted much interest in the occurrence of second primary cancers in patients with a first primary malignancy of organs involved in the immune response. SOUADJIAN et al. (1968) discovered that 21% of 146 thymoma patients followed for 20 years developed a non-thymic malignancy.
3% of the patients with cancer of the buccal cavity and pharynx were male. This cohort of individuals contributed approximately 24,130 person-years of observation. Results. Detailed tabulations by site are presented in Tables 5-19. The reader is referred to Chapter 5 for a general explanation of the items in these tables. Summary of Findings. Site-group pairs with a statistically significant excess of observed over-expected subsequent primary cancers are categorized in Table 20 on the basis of possible relationships between the anatomic sites containing these cancers.