Download Next Generation Sequencing in Cancer Research: Volume 1: by Chee-Seng Ku, Yudi Pawitan, Mengchu Wu (auth.), Wei Wu, Hani PDF

By Chee-Seng Ku, Yudi Pawitan, Mengchu Wu (auth.), Wei Wu, Hani Choudhry (eds.)

​​​​This quantity presents an interdisciplinary viewpoint of employing subsequent new release Sequencing (NGS) know-how to melanoma study. It goals to systematically introduce the concept that of NGS, various NGS structures and their useful implications in melanoma biology.This detailed and entire textual content will combine the exceptional NGS know-how into numerous melanoma learn tasks instead of so much books which provide a close description of the expertise. This quantity will current real experimental effects with concrete information processing pipelines, talk about the bottleneck of every platform for actual undertaking in melanoma learn. in more, unmarried melanoma mobilephone sequencing because the evidence of proposal should be brought during this e-book, besides state-of-the-art details supplied may also help the meant viewers to strengthen a finished realizing of the NGS know-how and useful complete genome sequencing information research and quickly translate into their very own study, particularly within the box of melanoma biology.

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Additional info for Next Generation Sequencing in Cancer Research: Volume 1: Decoding the Cancer Genome

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1 summarises the pros and cons of different NGS-based methods to study DNA methylation, as well as the principle behind this approach. MethylC-seq was used to discover that methylation at non-CpG dinucleotides such as CHG and CHH (where H = A, C or T) occurs in embryonic stem cells and pluripotent stem cells, a finding that would not have been possible using microarray [14]. Approximately 25 % of methylation was detected at non-CpG sites, with enrichment observed in gene bodies but depletion in protein binding sites and enhancers.

Next-generation genomics: an integrative approach. Nat Rev Genet. 2010;11(7):476–86. Epub 2010/06/10. 8. Ku CS, Naidoo N, Wu M, Soong R. Studying the epigenome using next generation sequencing. J Med Genet. 2011;48(11):721–30. Epub 2011/08/10. 1 The Evolution of High-Throughput Sequencing Technologies… 27 9. Naidoo N, Pawitan Y, Soong R, Cooper DN, Ku CS. Human genetics and genomics a decade after the release of the draft sequence of the human genome. Hum Genomics. 2011;5(6):577– 622. Epub 2011/12/14.

Walsh T, Lee MK, Casadei S, Thornton AM, Stray SM, Pennil C, et al. Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing. Proc Natl Acad Sci U S A. 2010;107(28):12629–33. Epub 2010/07/10. 36. Pritchard CC, Smith C, Salipante SJ, Lee MK, Thornton AM, Nord AS, et al. ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencing. J Mol Diagn. 2012;14(4):357–66. Epub 2012/06/05. 37.

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