By Orla M. Conneely, Christiane Otto
Progestins play a key position in reproductive endocrinology and as pharmaceutical medicines for birth control and in mixed hormone treatment. To additional our knowing of progestin motion within the mammary gland, a world symposium, attended via prime researchers from academia and undefined, was once held in Berlin, 21–23 March 2007. Genetic mouse types helped to explain the function of progestins, either in general breast improvement and in affliction. Mechanistic molecular reports encouraged the layout of recent progestins with greater tissue selectivity. additionally, the scientific impression of progesterone receptor agonists and antagonists for the prevention and remedy of breast melanoma used to be mentioned.
Read or Download Progestins and the Mammary Gland: From Basic Science to Clinical Applications (Ernst Schering Foundation Symposium Proceedings) PDF
Similar cancer books
Cancer Cell Culture: Methods and Protocols
With many fresh advances, melanoma cellphone tradition study is extra very important than ever ahead of. This well timed variation of melanoma phone tradition: equipment and Protocols covers the fundamental ideas of melanoma telephone biology and tradition whereas increasing upon the new shift in mobilephone tradition tools from the iteration of latest telephone strains to using basic cells.
Die tierische Zelle in Zellkultur
Die ersten erfolgreichen Versuche zur Züchtung tierischer Zellen außerhalb des Organismus reichen zurück in den Beginn unseres Jahrhunderts. 1907 gelang HARRI SON durch Explantation von Gewebsstücken aus Froschembryonen der Nachweis, daß in der Embryonalentwicklung die Neuriten als Fortsätze der Nervenzelle ohne Be teiligung anderer Zellen gebildet werden, und daß damit eine spezifische celluläre Funktion auch außerhalb des Gesamtorganismus zu beobachten ist [310,311].
Port-Site and Wound Recurrences in Cancer Surgery: Incidence - Pathogenesis - Prevention
Up to now nine years, experiences of 'port-site' deposits following laparoscopic surgical procedure for malignancy, specially laparoscopic resection of colonic melanoma, have solid a shadow at the knowledge of the laparoscopic method within the surgical guy agement in sufferers with melanoma. these reviews of port-site deposits, a few ninety instances pronounced within the literature as much as 1999, have opened a 'can of worms' and highlighted the shortage of our wisdom on melanoma mobile migration from sturdy tu mors and the criteria that underlie their winning implantation in surgical wounds either within the presence and lack of a good strain pneumoperito neum.
- I Am Not My Breast Cancer: Women Talk Openly About Love and Sex, Hair Loss and Weight Gain, Mothers and Daughters, and Being a Woman with Breast Cancer
- Thyroid Cancer
- Cox-2: a new target for cancer prevention and treatment
- Stand by Her: A Breast Cancer Guide for Men
- Physics of Mammographic Imaging
Additional info for Progestins and the Mammary Gland: From Basic Science to Clinical Applications (Ernst Schering Foundation Symposium Proceedings)
Sample text
6 RU486 Modulates PR Activity Through MAP Kinase Signaling Pathways . . . 7 A Tissue-Specific Partnership Exists Between PR and SRCs in Female Reproductive Organs . . . 8 Uterine PR Requires SRC-1 . . . . . . . 9 SRC-3 Is Involved in PR-Mediated Gene Regulation in the LECs of Mammary Gland . . . . . 10 Factors Involved in Tissue-Specific Functional Interactions Between PR and Specific SRCs . . References . . . . . . . . . . . . . . . . . 27 . . . .
Transgenic expression of either Wnt1 or β-catenin results in widespread mammary hyperplasia and tumour formation (Imbert et al. 2001; Tsukamoto et al. 1988). The hyperplastic tissue contains increased numbers of stem/ progenitor cells, which are thought to be directly responsible for transformed cells. Tumours that arise from stem/progenitor cells are heterogeneous showing cells of mixed lineage. Tumours that arise from Wnt activation also contain cells of both epithelial lineages (Li et al. 2003, 2004; Owens and Watt 2003; Shackleton et al.
1995). Therefore, PR also has crucial roles in mammary gland development in mouse. Although studies using PR–/– mice revealed the critical importance of PR in vivo, we have been unable to investigate the temporal and spatial distribution of PR activity in vivo. Therefore, we created an animal model in which we could investigate the dynamic changes in PR activity in response to various hormonal stimuli in vivo. 1 The PRAI Mouse Is a Novel Animal Model to Investigate PR Activity in vivo Most previous studies investigating the molecular mechanisms regulating PR activity have utilized transient cell transfection assays as the major molecular biology technique.