By Christiane Schaffitzel, Nenad Ban (auth.), Greta Pifat-Mrzljak (eds.)
An huge, immense quantity of latest wisdom at the molecular foundation of assorted organic phenomena has emerged within the quickly increasing box of bioscience. because the frontiers in clinical examine are tough to outline‚ the construction of latest wisdom relies not just on new tools and ideas but in addition on interplay with different fields of study. the rules and strategies of biophysics will be a rational language for dialogue not just among scientists of the several disciplines of common sciences‚ similar to physics‚ arithmetic‚ biochemistry‚ molecular biology and biotechnology‚ but additionally for drugs and social sciences to boot. this is often the overall philosophy in the back of the association of the summer season faculties geared up via Rudjer Institute‚ Zagreb‚ Croatia and the Croatian Biophysical Society. The overseas summer time colleges on Biophysics have a really extensive scope. this is often not like the opposite workshops or faculties that are concentrated as a rule on one subject or method. The goal was once to prepare classes which supplied complicated education at doctoral or postdoctoral point in biosciences. hence‚ the colleges primarily have a catalytic position and are complementary to‚ instead of competing with‚ actions of parallel nationwide or overseas programmes.
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For example‚ the proton pump blocker omeprazole‚ recently introduced to market in single enantiomer dosage form‚ possesses a stereogenic center that is lost upon degradation of the applied prodrug form4. Both enantionomeric forms of the inflammatory drug ibuprofen show clearly deviating in vitro activity‚ however the in-vivo inactive R-form is metabolized through inversion of its stereocenter into the active S-enantiomer (Fig. 3). 34 Gerhard Klebe Figure 2 Chemical formulae of some of the best selling drugs.
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Hubbard‚ T. Critical assessment of methods of protein structure prediction (CASP): round IV. Proteins Suppl 5‚ 2-6 (2001). 28. ‚ Fidelis‚ K. & Pedersen‚ J. Critical assessment of methods of protein structure prediction (CASP): round III. Proteins Suppl 3‚ 2-6 (1999). ‚ Fidelis‚ K. & Pedersen‚ J. Critical assessment of methods of protein structure prediction (CASP): round II. Proteins Suppl 1‚ 2-6 (1997). ‚ Judson‚ R. & Fidelis‚ K. A large-scale experiment to assess protein structure prediction methods.