By Hans H. Kreipe MD, Reinhard von Wasielewski MD (auth.), Prof. Dr. med. Manfred Dietel (eds.)
From its creation, oncological chemotherapy has been weighted down by way of its terrible selectivity simply because such a lot antiproliferative medicines are poisonous not just to tumor cells but additionally to special populations of the body’s non-neoplastic cells. the consequent issues of side effects are compounded via problems in predicting the specified efficiency of chemotherapy in person patients.
This unsatisfactory scenario has pushed extensive examine and improvement in the direction of extra particular and no more poisonous anticancer medicinal drugs over the past few many years. numerous result of those efforts have reached the health facility and an excellent larger quantity are actually in preclinical testing.
Common to these types of particular treatments is their interplay with outlined molecules current on melanoma cells, which provides numerous levels of elevated selectivity to their poisonous results. accordingly, detecting the objective molecule on tumors prior to treatment holds nice diagnostic strength for predicting the efficacy of the drug and personalizing remedy.
This booklet goals to offer translational scientists and clinicians with an built-in severe view at the theories, mechanisms, difficulties and pitfalls of the special remedy approach.
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An individual prediction profile for the resistance against each chemotherapy agent was constructed, containing 42 to 297 genes. 7%. A list of the top 67 multi-drug-resistance candidate genes which were associated with the resistance against at least four anti-cancer agents was identified. Moreover, the differential expressions of 46 selected genes were also measured by quantitative RT-PCR using a TaqMan microfluidic card system. As a single gene can be correlated with resistance against several agents, we sought associations with resistance by examining, altogether, 76 different genes and resistance phenotypes.
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G. fluorescence in-situ hybridization, FISH) of single target molecules is still insufficient. For the identification of those patients who will benefit from novel therapies, special methods capable of detecting the entire spectrum of rate-limiting oncogenic pathways in tumours prior to and during therapy have to be developed and adapted to routine diagnostic pathology. Clearly this will play an increasing role in the future tasks of pathological institutes. 6 Discussion Gene expression profiling can be helpful for the pre-treatment assessment of anti-cancer therapy.