By Robert A. Weinberg
Completely up to date and incorporating crucial advances within the fast-growing box of melanoma biology, The Biology of Cancer, moment variation, continues all of its hallmark gains trendy by way of scholars, teachers, researchers, and clinicians round the world.
The Biology of Cancer is a textbook for college kids learning the molecular and mobile bases of melanoma on the undergraduate, graduate, and scientific college degrees. the rules of melanoma biology are offered in an equipped, cogent, and in-depth demeanour. The readability of writing, supported by way of an intensive full-color artwork software and diverse pedagogical gains, makes the e-book obtainable and interesting. the knowledge unfolds throughout the presentation of key experiments that supply readers a feeling of discovery and supply insights into the conceptual starting place underlying smooth melanoma biology.
The new moment variation has been comprehensively revised and up-to-date to incorporate significant advances in melanoma biology during the last six years. Updates comprise present details on:
• The tumor microenvironment
• Metastatic dissemination
• Tumor immunology
• melanoma stem cells
• The epithelial-mesenchymal transition
• Multi-step tumorigenesis
• Invasion and metastasis
• Mutation of melanoma telephone genomes
• vastly increased therapy of conventional therapy
• Epigenetic contributions
• MicroRNA involvement
• The Warburg effect
Besides its price as a textbook, The Biology of Cancer is an invaluable reference for people operating in biomedical laboratories and for medical professionals.
Every reproduction of the booklet comes with an up-to-date "Pathways in Human Cancer" poster and a DVD-ROM containing the book’s paintings software, a enormously improved choice of video clips, audio dossier mini-lectures, Supplementary Sidebars, and a Media Guide.
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Additional resources for The Biology of Cancer
Example text
10 Cancer-causing mutations affect the germ line and soma 1 2 3 6 7 8 13 14 15 19 20 21 4 9 10 16 22 X 5 11 12 17 18 (B) markers hsr (A) frequency of transcripts 80 60 (C) 40 20 0 (E) 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 chromosome lymphoma Wilms tumor rhabdomyosarcoma ependymoma glioblastoma neuroblastoma medulloblastoma Ewing's sarcoma acute lymphoblastic leukemia (D) the arrow, while many dozens of DMs are apparent. 9) in a human interstitial deletion, right) following extensive exposure to radiation neuroendocrinal tumor has caused an entire stretch of from plutonium.
B) The availability of DNA probes that hybridize specifically to various genes now makes it possible to localize genes along a chromosome by tagging each probe with a specific fluorescent dye or combination of dyes. Shown are six genes that were localized to various sites along human Chromosome 5 by using fluorescence in situ hybridization (FISH) during metaphase. ) (A, from M. Singer and P. Berg, Genes and Genomes. B. Bridges, J. Hered. 26:60, 1935. B, courtesy of David C. 9 Physical maps of human sex chromosomes (A) Shown is a scanning electron micrograph of human X and Y chromosomes.
The altered nucleotides may then be excised by DNA repair enzymes (Chapter 12) and replaced by cytidine; alternatively, when DNA bearing an oxidized cytidine is replicated, the maintenance methylase may fail to methylate the complementary strand. This research has not yet identified how the Tet enzymes are controlled. The methyl CpG groups do not, on their own, directly block transcription. Instead, they appear to affect the structure of the chromatin proteins that are responsible for packaging chromosomal DNA and presenting it to RNA polymerases for transcription, Me Me CpG Me GpC CpG replication GpC Me newly synthesized daughter strands CpG GpC Me CpG maintenance DNA methyltransferase adds new methyl groups to the recently synthesized daughter strands GpC Me Me CpG GpC Me Unconventional RNA molecules also affect gene expression as described above.