By J. Robert Oppenheimer
1969
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For example‚ the proton pump blocker omeprazole‚ recently introduced to market in single enantiomer dosage form‚ possesses a stereogenic center that is lost upon degradation of the applied prodrug form4. Both enantionomeric forms of the inflammatory drug ibuprofen show clearly deviating in vitro activity‚ however the in-vivo inactive R-form is metabolized through inversion of its stereocenter into the active S-enantiomer (Fig. 3). 34 Gerhard Klebe Figure 2 Chemical formulae of some of the best selling drugs.
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