By Richard Horton
Read Online or Download The Lancet – Volume 377, Number 9759 (2011 - January - 1) PDF
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Additional resources for The Lancet – Volume 377, Number 9759 (2011 - January - 1)
Example text
InFACT: a global critical care research response to H1N1. Lancet 2010; 375: 11–13—In this Comment (Jan 2), the name of the third member of the InFACT Global H1N1 Collaboration was misspelled. The correct spelling is “Neill K J Adhikari”. This correction has been made to the online version as of Dec 31, 2010. com Vol 377 January 1, 2011 Articles Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials Peter M Rothwell, F Gerald R Fowkes, Jill F F Belch, Hisao Ogawa, Charles P Warlow, Tom W Meade Summary Background Treatment with daily aspirin for 5 years or longer reduces subsequent risk of colorectal cancer.
The only evidence of a possible effect of increased investigation in the aspirin groups was a transient increase in risk of deaths attributed to stomach cancer during the trials, and a transient reduction in deaths attributed to cancers with unknown primary site (table 1). Moreover, the complete lack of any effect of warfarin on cancer deaths in TPT suggests that 37 Articles Aspirin vs placebo Risk of cancer death (%) 2·5 2 2 1·5 p=0·008 1 1 0·5 0·5 Risk of cancer death (%) 5 10 Years to death 15 20 2402 2404 2197 2189 1913 1883 410 412 0 Number at risk Aspirin 2545 Control 2540 0 8 6 6 p=0·0002 4 p=0·99 0 5 10 Years to death 15 20 2409 2397 2205 2181 1896 1900 407 415 15 20 1896 1900 407 415 15 20 2179 2158 1845 1849 397 400 5 10 Years to death 15 20 2409 2397 2205 2181 1896 1900 407 415 Gastrointestinal adenocarcinoma p=0·91 4 2 2 0 5 Number at risk Aspirin 2545 Control 2540 10 Years to death 2402 2404 2197 2189 15 20 1913 1883 410 412 0 8 6 6 p=0·09 4 0 5 Number at risk Warfarin 2545 Control 2540 8 Prostate adenocarcinoma 10 Years to death 2409 2397 2205 2181 Prostate adenocarcinoma p=0·69 4 2 2 0 Lung adenocarcinoma Number at risk Warfarin 2545 Control 2540 8 Gastrointestinal adenocarcinoma 0 Risk of cancer (%) 2·5 1·5 0 0 Number at risk Aspirin 2545 Control 2540 14 Risk of cancer death (%) Warfarin vs placebo Control Aspirin Lung adenocarcinoma 5 10 Years to notification 15 20 2388 2387 2173 2164 1859 1835 400 397 0 14 All fatal adenocarcinoma 12 10 10 10 Years to notification 2394 2381 All fatal adenocarcinoma 8 p<0·0001 6 5 Number at risk Warfarin 2545 Control 2540 12 8 0 p=0·84 6 4 4 2 2 0 0 0 5 10 15 20 1913 1883 410 412 0 Years to death Number at risk Aspirin 2545 Control 2540 2402 2404 2197 2189 Number at risk Warfarin 2545 Control 2540 Figure 6: Comparison of effect of allocation to aspirin or warfarin versus placebo on risk of death due to adenocarcinoma during long-term follow-up of the Thrombosis Prevention Trial17 Analysis includes all patients, irrespective of scheduled duration of trial treatment.
Am J Epidemiol 2010; 172: 1292–98. Armstrong BK, White E, Saracci R. Principles of exposure measurement in epidemiology. New York: Oxford University Press, 1992. Rothman KJ, Greenland S, Lash TL. Validity in epidemiologic studies. In: Rothman KJ, Greenland S, Lash TL. Modern epidemiology, 3rd edn. Philadelphia: Lippincott Williams & Wilkins, 2008: 137–46. uk Department of Histopathology, Nottingham University Hospitals, City Hospital Campus, Nottingham NG5 1PB, UK 1 2 3 Kang S. Anecdotes in medicine—15 years of Lancet case reports.