Download The Role of Chromosomes in Cancer Biology by Peo C. Koller Ph. D., D. Sc. (auth.) PDF

By Peo C. Koller Ph. D., D. Sc. (auth.)

Show description

Read or Download The Role of Chromosomes in Cancer Biology PDF

Best cancer books

Cancer Cell Culture: Methods and Protocols

With many fresh advances, melanoma phone tradition examine is extra very important than ever prior to. This well timed variation of melanoma mobile tradition: equipment and Protocols covers the fundamental options of melanoma mobilephone biology and tradition whereas increasing upon the hot shift in telephone tradition tools from the iteration of recent mobilephone strains to using basic cells.

Die tierische Zelle in Zellkultur

Die ersten erfolgreichen Versuche zur Züchtung tierischer Zellen außerhalb des Organismus reichen zurück in den Beginn unseres Jahrhunderts. 1907 gelang HARRI­ SON durch Explantation von Gewebsstücken aus Froschembryonen der Nachweis, daß in der Embryonalentwicklung die Neuriten als Fortsätze der Nervenzelle ohne Be­ teiligung anderer Zellen gebildet werden, und daß damit eine spezifische celluläre Funktion auch außerhalb des Gesamtorganismus zu beobachten ist [310,311].

Port-Site and Wound Recurrences in Cancer Surgery: Incidence - Pathogenesis - Prevention

Up to now nine years, studies of 'port-site' deposits following laparoscopic surgical procedure for malignancy, particularly laparoscopic resection of colonic melanoma, have forged a shadow at the knowledge of the laparoscopic process within the surgical guy­ agement in sufferers with melanoma. these studies of port-site deposits, a few ninety situations mentioned within the literature as much as 1999, have opened a 'can of worms' and highlighted the shortage of our wisdom on melanoma cellphone migration from stable tu­ mors and the criteria that underlie their profitable implantation in surgical wounds either within the presence and lack of a favorable strain pneumoperito­ neum.

Additional resources for The Role of Chromosomes in Cancer Biology

Sample text

12 shows that over a fifteen year time period the modal number varied between 50 and 65 (KOLLER, 1960). 26 Malignant Cell Populations and the Stemline Concept Since ISHIBASHI'S successful transmission of Yoshida sarcoma by one cell inoculation (1950), many tumour clones have been established. The chromosome constitution of several clones of EHRLICH and Krebs-2 ascites tumours of mice were Fig. 13a Fig. 13. Chromosome constitution and karyotype of two cells in HeLa strain: a) 55 chromosomes, b) 109 chromosomes; in both cells several chromosomes have altered morphology (By courtesy of Dr.

The best known human cell line is HeLa, isolated from a biopsy of a human cervical carcinoma by GEY and his associates in 1952. HeLa was grown in vitro for three years before its chromosomes were studied by Hsu (1954 a) who found a very wide spectrum of variation in chromosome number, ranging from 50 to several hundreds, and reported the modal number to be 83. The chromosomal constitution of secondary clones of HeLa were analysed by CHU and GILES (1958) who observed different numerical and structural changes in the various clones, and differences in the frequency of cells with the modal chromosome number.

Transplant generation were cultured in vitro, and dividing cells in the culture were followed by cinephotography. In the culture no cells with anaphase chromosome bridges were found, yet when these cultured cells were re-transplanted into animals and a tumour developed, cells with chromosome bridges re-appeared (KOLLER and WAYMOUTH, 1952). It seems that the expression of cellular instability is under the influence of the environment, in vivo it persisted up to the 93rd. transplant generation. The cytological study of this particular tumour shows that structural and numerical alterations in chromosome constitution can arise in malignant cells not only in the initial phase of tumour development, but at any stage in the growth of the tumour.

Download PDF sample

Rated 4.10 of 5 – based on 24 votes