By R. Dulbecco (auth.), Alan Kolber (eds.)
The oncogenic virus can purely be studied as a carcinogen while its relation to the host phone within which it is living is known. The interplay among tumor virus and host mobile was once the topic of a contemporary North Atlantic Treaty association complicated examine I~stitute. This quantity is the edited court cases of this research institute. One challenge of basic value in knowing malignant transformation is the mechanism during which the oncogenic vector promotes the aberrations within the host mobile regulatory appara tus leading to a cancerous telephone. it truly is in part the aim of this quantity to assist make clear this challenge, and to stimulate the curiosity of others to proceed the examine essential to this finish. The assembly from which this quantity is compiled came about within the Principality of Monaco with the patronage of Her Serene excessive ness, Princess Grace and used to be supported mostly by means of a provide from the North Atlantic Treaty association. The editor needs to thank the North Atlantic Treaty association, Princess Grace of Monaco, and the Bureau de Tourism Monaco for his or her beneficiant help. Addi tional monetary tips used to be supplied by means of the Deutsches Studium Gesellschaft and that i wish to thank Prof. Klaus Munk, Deutsches Krebsforschungszentrum, for his assist in acquiring this reduction. i might additionally prefer to thank the Verwaltung of the Deutsches Krebsfor schungszentrum for his or her administrative help.
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Thoren, M. , E. D. Sebring, and N. P. Salzman. 10:462-468. , and J. Lebowitz. 1971. 1966. 1972. J. Gen. Physiol. J. Virol. 49:103-126. , A. Schlabach, B. Fridlender, and A. Bolden. Nature New Biol. 231:167-170. 1971. THE REPEATED SEQUENCES IN SERIALLY PASSAGED SV40 DNA N. Frenkel, S. Rozenblatt, and E. Winocour Virology Section, Weizmann Institute of Science Rehovot, Israel ABSTRACT Three populations of altered SV40 DNA molecules, independently derived by serial passage of plaque-purified virus at high multiplicity of infection, were found to contain reiterated viral sequences, as determined by reassociation kinetic experiments.
LEVINE II A B PARENTAL STRAND PARENTAL STRAND II I IHd ~o! II~ ~b4 IIHd '5 PROGENY 4-5 S FRAGMENTS STRAND 'S 5' 'S 'S :L I: I HO I I I I I I I I I 3' PROGENY STRAND ~ 5' 3' ~-5' 3' 4-5 S FRAGMENTS FIG. 3. Possible structure for the hydrogen bonding of the 4-58 fragments in the replicative intermediates of HU-inhibited SV40 DNA. MOdel A: The 48 fragments are not separated from each other and the longer progeny strand. There is a break or a nick in the phosphodiester backbone of adjacent nucleotides bounded by a 3'-0H and a 5'-P04 group.