By Richard D. Ferguson
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Extra info for Lung Transplantation: Therapies, Complications and Outcomes (Organ Transplantation Research Horizons)
Sample text
Journal of Thoracic and Cardiovascular Surgery, 2007;133(6):1620-5. [49] Amital A, Shitrit D, Raviv Y, Saute M, Medalion B, Bakal L, et al. The use of surfactant in lung transplantation. Transplantation. 2008;86(11):1554-9. [50] Levine A, Parkes K, Rooney S, Bonser R. Reduction of Endothelial Injury After Hypothermic Lung Preservation by Initial Leukocyte-Depleted Reperfusion. J Thorac Cardiovasc Surg. 2000;120:47-54. [51] Clark S, Rao J, Flecknell P, Dark J. Pentoxifylline is as effective as leukocyte depletion for modulating pulmonary reperfusion injury.
96] Baretti R, Bitu-Moreno J, Beyersdorf, Matheis G, Francischetti I, Kreitmayr B. Distribution of lung preservation solutions in parenchyma and airways: influence of atelectasis and route of delivery. J Heart Lung Transplant, 1995;14:80–91. [97] Chen CZ, Gallagher RC, Ardery P, Dyckman W, Donabue S, Low HB. Retrograde flush and cold storage for twenty-two to twenty-five hours lung preservation with and without prostaglandin E1. J Heart Lung Transplant, 1997;16:658–666. [98] M, Alvarez-Antonan C, Arce-Mateos FP, Gomez-Roman J, Quesada-Suescun A, Zurbano-Goni F.
However, results of the use of aprotinin to attenuate PGD in the clinical setting have been conflicting [57,138-140]. Interestingly, investigation of the impact of adding aprotinin to newer preservation solutions has shown no improvement over Perfadex alone and a significant deterioration in postischaemic lung performance when used with Primary Graft Dysfunction in Lung Transplantation 19 Celsior[138]. Systemic use of aprotinin in the recipient during the implantation has also been shown to have a detrimental effect on post operative PGD [57], and a recent study in a brain death rat model showed no attenuation of IRI with aprotinin treatment [140].