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By Angus G. Dalgleish, Robin A. Weiss

HIV and the hot Viruses offers state-of-the-art studies of continual human virus infections as a coherent assortment for the 1st time. those disguise lately chanced on viruses reminiscent of HHV-6, HHV-8 and HCV, in addition to the newest study on HIV.This finished and up-to-date reference contains an in-depth research of the most important matters within the epidemiology, pathogenicity, molecular virology, host responses and administration of stipulations linked to these viruses. details on new prescribed drugs and vaccine advancements can also be included.Edited by means of the top specialists within the box, HIV and the recent Viruses might be crucial analyzing for postgraduates, clinicians and researchers in virology, immunology, melanoma, molecular biology and the pharmaceutical undefined. Key positive aspects* offers state-of-the-art reports of power human virus infections as a coherent assortment for the 1st time* contains an in-depth examine of the foremost matters within the epidemiology, pathogenicity, molecular virology, host responses, and administration of stipulations linked to these viruses

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20 H I V and the New Viruses REFERENCES Aboul-ela F, Karn J & Varani G (1995) The structure of the human immunodeficiency virus type1 TAR RNA reveals principles of RNA recognition by Tat protein. J Mol Biol 253: 313-332. Adams M, Sharmeen L, Kimpton J et al (1994) Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoterproximal transcripts. Proc Natl Acad Sci USA 91: 3862-3866. Alonso A, Derse D & Peterlin BM (1992) Human chromosome 12 is required for optimal inter.

J. Leigh Brown et al, unpublished observations). Concentration of future sequencing efforts on such well-characterized study groups is likely to be more informative than surveys of seroprevalent cases. EVOLUTION OF HIV WITHIN AN INDIVIDUAL At the earliest stages of the infection, the first 7-10 weeks, the virus is able to replicate to high titre levels, reaching 106 or 107 viral particles per ml of plasma (Piatak et al, 1993a,b). Studies of viral populations at this phase of infection have revealed low levels of sequence variability, especially in parts of the envelope glycoprotein gp 120 (Zhang et al, 1993; Zhu et al, 1993), whereas variation is detectable in gag (Zhang et al, 1993).

J Virol 64: 5448-5456. Selby MJ & Peterlin BM (1990) Trans-activation by HIV-1 Tat via a heterologous RNA binding protein. Cell 62: 769-776. Selby MJ, Bain ES, Luciw PA & Peterlin BM (1989) Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat. Genes Dev 3: 547-558. Sheldon M, Ratnasabapathy R & Hernandez N (1993) Characterization of the inducer of short transcripts, a human immunodeficiency virus type 1 transcriptional element that activates the synthesis of short RNAs.

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