By G. Mathé (auth.), Georges Mathé, Roy Weiner M.D. (eds.)
G.MATHE Institut de Cancerologie et d'Immunogenetique (INSERM et organization Claude-Bernad), H6pital Paul-Brousse and Institute Gustave-Roussy, Villejuif twenty years in the past, the most, if not just item of the melanoma therapist was once to influence entire surgical exeresis or radiotherapeutic destruction of a neighborhood tumor, or to procure, via chemotherapy, an "apparently whole regression" of an area or disseminated neoplasia. this present day it's discovered that (a) on the time of the operation or radiotherapy, sufferers in each 3 sporting an it sounds as if localized tumor have a couple of melanoma cells outdoor the world the place the tumor turns out localized; (b) while "apparently whole regression" or perhaps an "apparently entire remission" is caused through chemotherapy, no longer the entire neoplastic cells were eliminated. In either instances an imperceptible residual neoplasm persists, the expansion of on the way to in the end make it perceptible back, giving upward push to metastasis or to a systemic or localized relapse. there's hence an pressing want for a brand new approach in a position to killing the final telephone or cells. Our experiments in mice at the effectiveness of lively immunotherapy, which consists of the manipulation of the immune equipment, have proven that this remedy is ready to kill all of the cells, all the way down to the final telephone of a given leukemia, only if the full variety of cells doesn't exceed a number of thousand [1, 2].
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Extra resources for Investigation and Stimulation of Immunity in Cancer Patients
Example text
Neg. No recurrence Recurrence 12 2 5 14 2 14 7 21 7 Acknowledgement The authors wish to thank analysis. DAVID SCHOTTENFELD for assistance in the statistical References 1. , VAITKEVICruS, V. : Clinical immunologic responsiveness in malignant disease. 1. Delayed hypersensitivity reaction and the effect of cytotoxic drugs. ) 26, 262 (1970). 2. BROWN, R. , HAYNES, H. , FOLEY, T. , GODWIN, H. , BERARD, C. , URBaNE, P. : Hodgkin's disease, immunologic, clinical, and histologic features of 50 untreated patients.
_... :_---- 20 .. '{... 2 month COMPlIlE REMISSION CELL-REDUCING COMPLEMENTARY INDUCTiON CHEMOTHERAPY SYSTEMIC AND CNS CHEMORADIOTHERAPY ACTIVE IMMUNOTHERAPY Fig. 1. Acute lymphoid leukemia: 54 patients. Kinetics of immune responses evaluated by a routine battery of tests poor short-term prognosis. One notes as well that there is an improvement in the results of the tests while the patient is undergoing immunotherapy. However, we must point out that these results have only statistical value, that they apply to a patient population, not to any single patient, and it is thus impossible to draw any therapeutic conclusions from this information.
Several studies have suggested that this is indeed true. Thus, several investigators [2, 7, 8, 11] have found that immunological evaluation of solid tumor and lymphoma patients prior to treatment could identify patients with a good prognosis on the basis of their immunocompetence. Furthermore, the state of immunocompetence following therapy may be even more important than that prior to therapy in determining the patient's prognosis. We have shown in several studies [1, 5, 6], that recovery or overshoot of immunocompetence or both, after one or more courses of chemotherapy correlates with a good prognosis in both solid-tumor and acute leukemia patients.